Baselodge Group » Pharmasourcing » Samuel F. Lockwood, MD

Samuel F. Lockwood, MD

On this page you will find Dr. Lockwood’s selected publications, issued U.S. patents, and published patent applications.

For reprints of scientific articles, please contact Dr. Lockwood at slockwood@baselodge.com.

Dr. Lockwood’s bio can be found here.

Selected Publications top

Bradley, R. D., Davis, S. K., Lockwood, S. F., Bickham, J. W., Baker, R. J. 1991. Hybrid breakdown and cellular DNA content in a contact zone between two species of pocket gophers (Geomys). J. Mammal., 72, 697-705.
Lockwood, S. F., Bickham, J. W. 1991. Genetic stock assessment of spawning arctic cisco (Coregonus autumnalis) populations by flow cytometric determination of DNA content. Cytometry, 12, 260-267.
Lockwood, S. F., Holland, B. S., Bickham, J. W., Hanks, B. G., Bull, J. J. 1991. Intraspecific genome size variation in a turtle (Trachemys scripta) exhibiting temperature-dependent sex determination. Can. J. Zool., 69, 2306-2310.
Lockwood, S. F., Seavey, B. T., Dillinger, R. E. J., Bickham, J. W. 1991. Variation in DNA content among age classes of broad whitefish (Coregonus nasus) from theSagavanirktok River delta. Can. J. Zool., 69, 1335-1338.
Lockwood, S. F., Pope, D. H. 1992. Final report on biocorrosion/biodeterioration/biofouling of coated metals. Office of Naval Research, contract number N-6092191-C-0181. DCMR, Dallas, Texas.
Lockwood, S. F., Pope, D. H. 1992. Final report on identification of microbially influenced corrosion. Office of Naval Research, contract number N-00014-92-C-0068. DCMR, Dallas, Texas.
Lockwood, S. F., Bickham, J. W. 1992. Genome size in Beaufort Sea coastal assemblages of Arctic ciscoes. Trans. Am. Fish. Soc., 121, 13-20.
Lockwood, S. F., Derr, J. N. 1992. Intra- and interspecific genome-size variation in the Salmonidae. Cytogenet. Cell Genet., 59, 303-306.
Pope, D. H., Dziewulski, D. M., Lockwood, S. F., Werner, D. P., Frank, J. R. 1992. Microbiological corrosion concerns for pipelines and tanks. API Pipeline Conference.Houston, Texas.
Pope, D. H., Lockwood, S. F. 1992. Microbiologically influenced corrosion in the natural gas industry. Topical Report (February 1986-September 1990). GRI Report Number 92-0469. Gas Research Institute, Chicago, Illinois.
Pope, D. H., Dziewulski, D. M., Lockwood, S. F., Werner, D. P., Frank, J. R. 1992. Microbiologically influenced corrosion of gas transmission pipelines. AGA Distribution and Transmission Conference. Kansas City, Missouri.
Walsh, D. W., Lockwood, S. F., Werner, D. P., Paakkonen, S. T., Pope, D. H. 1992. Effects of welding on the susceptibility of materials to microbiologically influenced corrosion in geothermal applications. In Geothermal resources council transactions; Geothermal Resources Council: Davis, CA; Vol. 16, pp. 377-383.
Lockwood, S. F., Dillinger, R. E., Jr., Birt, T. P., Green, J. M., Snyder, T. P. 1993. Phylogenetic relationships among members of the Coregoninae inferred from direct sequencing of PCR-amplified mitochondrial DNA. Can. J. Fish. Aquat. Sci., 50, 2112-2118.
Paakkonen, S. T., Lockwood, S. F., Pope, D. H., Horner, V. G., Morris, E. A. III, Werner, D. P. 1993. The role of coatings and cathodic protection in microbiologically influenced corrosion. Corrosion 93. Paper No. 293/pp. 1-21.
Pope, D. H., Lockwood, S. F., Lee, A., Skultety, R., Keas, K. 1994. Mitigation of microbiologically influenced corrosion in natural gas industry storage facilities. Corrosion 94. Paper No. 269/pp. 1-15.
Kocher, T. D., Conroy, J. A., McKaye, K. R., Stauffer, J. R., Lockwood, S. F. 1995. Evolution of NADH dehydrogenase subunit 2 in east African cichlid fish. Mol. Phylogenet. Evol., 4, 420-432.
Lockwood, S. F., O’Malley, S., Mosher, G. L. 2003. Improved aqueous solubility of crystalline astaxanthin (3,3′-dihydroxy-b,b-carotene-4,4′-dione) by Captisol (sulfobutyl ether beta-cyclodextrin). J. Pharm. Sci., 92, 922-926.
Cardounel, A. J., Dumitrescu, C., Zweier, J. L., Lockwood, S. F. 2003. Direct superoxide anion scavenging by a disodium disuccinate astaxanthin derivative: relative efficacy of individual stereoisomers versus the statistical mixture of stereoisomers by electron paramagnetic resonance imaging. Biochem. Biophys. Res. Commun., 307, 704-712.
Zsila, F., Simonyi, M., Lockwood, S. F. 2003. Interaction of the disodium disuccinate derivative of meso-astaxanthin with human serum albumin: from chiral complexation to self-assembly. Bioorg. Med. Chem. Lett., 13, 4093-4100.
Gross, G. J., Lockwood, S. F. 2004. Cardioprotection and myocardial salvage by a disodium disuccinate astaxanthin derivative (Cardax™). Life Sci., 75, 215-224.
Showalter, L. A., Weinman, S. A., Østerlie, M., Lockwood, S. F. 2004. Plasma appearance and tissue accumulation of non-esterified, free astaxanthin in C57BL/6 mice after oral dosing of a disodium disuccinate diester of astaxanthin (Heptax™). Comp. Biochem. Physiol. C. Toxicol. Pharmacol., 137, 227-236.
Hix, L. M., Lockwood, S. F., Bertram, J. S. 2004. Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivatives. Cancer Lett., 211, 25-37.
Foss, B. J., Sliwka, H. R., Partali, V., Cardounel, A. J., Zweier, J. L., Lockwood, S. F. 2004. Direct superoxide anion scavenging by a highly water-dispersible carotenoid phospholipid evaluated by electron paramagnetic resonance (EPR) spectroscopy. Bioorg. Med. Chem. Lett., 14, 2807-2812.
Hix, L. M., Lockwood, S. F., Bertram, J. S. 2004. Bioactive carotenoids: potent antioxidants and regulators of gene expression. Redox Rep., 9, 181-191.
Jackson, H. L., Cardounel, A. J., Zweier, J. L., Lockwood, S. F. 2004. Synthesis, characterization, and direct aqueous superoxide anion scavenging of a highly water-dispersible astaxanthin-amino acid conjugate. Bioorg. Med. Chem. Lett., 14, 3985-3991.
Hix, L. M., Vine, A. L., Lockwood, S. F., Bertram, J. S. 2005. Retinoids and carotenoids as cancer chemopreventive agents: role of up regulated gap junctional communication. In Carotenoids and retinoids: molecular aspects and health issues. Packer, L., Obermueller-Jevic, U., Kraemer, K., Sies, H., eds. AOCS Press:Champaign, IL, pp. 182-203
Frey, D. A., Kataisto, E. W., Ekmanis, J. L., O’Malley, S., Lockwood, S. F. 2004. The efficient synthesis of disodium disuccinate astaxanthin (Cardax). Org. Process. Res. Dev., 8, 796-801.
Zsila, F., Fitos, I., Bikádi, Z., Simonyi, M., Jackson, H. L., Lockwood, S. F. 2004. In vitro plasma protein binding and aqueous aggregation behavior of astaxanthin dilysinate tetrahydrochloride. Bioorg. Med. Chem. Lett., 14, 5357-5366.
Gross, G. J., Lockwood, S. F. 2005. Acute and chronic administration of disodium disuccinate astaxanthin (Cardax™) produces marked cardioprotection in dog hearts. Mol. Cell. Biochem., 272, 221-227.
Foss, B. J., Sliwka, H. R., Partali, V., Naess, S. N., Elgsaeter, A., Melø, T. B., Naqvi, K. R., O’Malley, S., Lockwood, S. F. 2005. Hydrophilic carotenoids: surface properties and aqueous aggregation of a rigid, long-chain, highly unsaturated dianionic bolaamphiphile with a carotenoid spacer. Chem. Phys. Lipids, 135, 157-167.
Zsila, F., Molnar, P., Deli, J., Lockwood, S. F. 2005. Circular dichroism and absorption spectroscopic data reveal binding of the natural cis-carotenoid bixin to human alpha-1 acid glycoprotein. Bioorg. Chem., 33, 298-309.
Lauver, D. A., Lockwood, S. F., Lucchesi, B. R. 2005. Disodium disuccinate astaxanthin (Cardax) attenuates complement activation and reduces myocardial injury following ischemia/reperfusion. J. Pharmacol. Exp. Ther., 314, 686-692.
Hix, L. M., Frey, D. A., McLaws, M. D., Østerlie, M., Lockwood, S. F., Bertram, J. S. 2005. Inhibition of chemically-induced neoplastic transformation by a novel tetrasodium diphosphate astaxanthin derivative. Carcinogenesis, 26, 1634-1641.
Zsila, F., Bikádi, Z., Lockwood, S. F. 2005. In vitro binding of leukotriene B₄ (LTB₄) to human serum albumin: evidence from spectroscopic, molecular modeling, and competitive displacement studies. Bioorg. Med. Chem. Lett., 15, 3725-3731.
Jackson, H. L., Nadolski, G. T., Braun, C., Lockwood, S. F. 2005. The efficient total synthesis of lycophyll (y,y-carotene-16,16′-diol). Org. Process Res. Dev., 9, 830-836.
Lockwood, S. F., Gross, G. J. 2005. Disodium disuccinate astaxanthin (Cardax™): antioxidant and antiinflammatory cardioprotection. Cardiovasc. Drug Rev., 23, 199-216.
Nadolski, G., Cardounel, A. J., Zweier, J. L., Lockwood, S. F. 2005. The synthesis and aqueous superoxide anion scavenging of water-dispersible lutein esters. Bioorg. Med. Chem. Lett., 16, 775-781.
Gross, G. J., Hazen, S. L., Lockwood, S. F. 2006. Seven day oral supplementation with Cardax^TM (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats. Mol. Cell. Biochem., 283, 23-30.
Braun, C. L., Jackson, H. L., Lockwood, S. F., Nadolski, G. 2006. Purification of synthetic all-e lycophyll (y,y-carotene-16,16′-diol). J. Chromatogr. B, 834, 208-212.
Lockwood, S. F., Penn, M. S., Hazen, S. L., Bikádi, Z., Zsila, F. 2006. The effects of oral Cardax™ (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo. Life Sci., 79, 162-174.
Zsila, F., Nadolski, G., Lockwood, S. F. 2006. Association studies of aggregated aqueous lutein diphosphate with human serum albumin and a₁-acid glycoprotein in vitro: evidence from circular dichroism and electronic absorption spectroscopy. Bioorg. Med. Chem. Lett., 16, 3797-3801.
Mason, R. P., Walter, M. F., McNulty, H., Lockwood, S. F., Byun, J., Day, C. A., Jacob, R. F. 2006. Rofecoxib increases susceptibility of human LDL and membrane lipids to oxidative damage: a mechanism of cardiotoxicity. J. Cardiovasc. Pharmacol., 47, [Suppl 1]:S7-S14.
Foss, B. J., Nadolski, G., Lockwood, S. F. 2006. Hydrophilic carotenoid amphiphiles: methods of synthesis and biological applications. Mini Reviews in Medicinal Chemistry, 6, 953-969.
Bikádi, Z., Hazai, E., Zsila, F., Lockwood, S. F. 2006. Molecular modeling of non-covalent binding of homochiral (3S,3′S)-astaxanthin to matrix metalloproteinase-13 (MMP-13). Bioorg. Med. Chem, 14, 5451-5458.
Lockwood, S. F., Jackson, H. L., Gross, G. J. 2006. Retrometabolic syntheses of astaxanthin (3,3’–dihydroxy–b, b–carotene–4,4’–dione) conjugates: a novel approach to oral and parenteral cardioprotection. Cardiovasc. Hematol. Agents Med. Chem., 4, 335-349.
Hazai, E., Bikádi, Z., Zsila, F., Lockwood, S. F. 2006. Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase. Bioorg. Med. Chem., 14, 6859-6867.
McNulty, H. P., Byun, J., Lockwood, S. F., Jacob, R. F., Mason, R. P. 2007. Differential effects of carotenoids on lipid peroxidation due to membrane interactions: X-ray diffraction analysis. Biochim. Biophysis. Acta, 1768, 167-174.
Naess, S. N., Sliwka, H. R., Partali, V., Melø, T. B., Naqvi, K. R., Jackson, H. L., Lockwood, S. F. 2007. Hydrophilic carotenoids: surface properties and aggregation of an astaxanthin-lysine conjugate, a rigid, long-chain, highly unsaturated and highly water-soluble tetracationic bolaamphiphile. Chemistry and Physics of Lipids, 148, 63-69.
Hazai, E., Bikádi, Z., Zsila, F., Lockwood, S. F. 2007. Non-covalent binding of disodium disuccinate astaxanthin to the catalytic site of phosphodiesterase 5A: a molecular modeling study. Letters in Drug Design & Discovery, 4, 128-136.
Sliwka, H.R., Melø, T. B., Foss, B. J., Abdel-Hafez, S. H., Partali, V., Nadolski, G., Jackson, H., Lockwood, S. F. 2007. Electron- and energy-transfer properties of hydrophilic carotenoids. Chemistry, 13(16), 4458-4466.
Bikádi, Z., Hari, P., Hazai, E., Lockwood, S. F., Zsila, F. 2008. Non-covalent binding of lycopene and lycophyll. In Lycopene–nutritional, medicinal and therapeutic properties. Preedy, V. R. and Watson, R. R. Eds. Science Publishers, Enfield, N. H., USA, pp. 65-81.
Sliwka, H.R., Partali, V., Lockwood, S. F. 2008. Hydrophilic carotenoids–carotenoid aggregates. In Carotenoids: physical, chemical, and biological functions and properties. Landrum, J. ed. CRC Press/Taylor and Francis, in press.
Khan, S.K., Malinski, T., Mason, R.P., Kubant, R., Jacob, R.F., Fujioka, K., Denstaedt, S.J., King, T.J., Hieber, A.D., Lockwood, S. F., Goodin, T. H., Pashkow, F. J., Bodary, P. F. 2010. Novel astaxanthin derivative (CDX 085) attenuates thrombosis in a mouse model. Journal of Thrombosis and Haemostasis (in press).

Issued U.S. Patents top

Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L. M, Jackson, H., Nadolski, G. 2006-12-05. Structural carotenoid analogs for the inhibition and amelioration of disease. US 7,145,025. Assignee Hawaii Biotech Inc. Originally published Aug. 19, 2004.
Lockwood, S. F., Tang, P. C., Nadolski, G. T., Jackson, H. L., Fang, Z., Du, Y., Yang, M., Geiss, W. B., Williams, R., Burdick, D. C. 2007-07-24. Methods for the synthesis of astaxanthin. US 7,247,752. Assignee: Cardax Pharmaceuticals, Inc. Originally published Apr. 27, 2006.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L. M., Jackson, H., Nadolski, G. 2008-01-08. Carotenoid ester analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury. US 7,317,008. Assignee Cardax Pharmaceuticals, Inc. Originally published Feb. 17, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L. M., Jackson, H., Nadolski, G. 2008-01-22. Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease. US 7,320,997. Assignee Cardax Pharmaceuticals, Inc. Originally published Apr. 7, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H., Nadolski, G. 2008-03-18. Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease. US 7,345,091. Assignee Cardax Pharmaceuticals, Inc. Originally published Jan. 13, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L. M., Jackson, H., Nadolski, G. 2008-05-20. Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease. US 7,375,133. Assignee Cardax Pharmaceuticals, Inc. Originally published Mar. 24, 2005.
Lockwood, S. F., Tang, P. C., Nadolski, G., Jackson, H. L., Fang, Z., Du, Y., Yang, M., Geiss, W., Williams, R., Burdick, D. 2008-10-14. Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates. US 7,435,861. Assignee Cardax Pharmaceuticals, Inc. Originally published Dec. 28, 2006.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L. M., Jackson, H., Nadolski, G. 2009-04-21. Carotenoid analogs or derivatives for the inhibition and amelioration of disease. US 7,521,584. Assignee Cardax Pharmaceuticals, Inc. Originally published May 26, 2005.
Lockwood, S. F., O’Malley, Watumull, D. G., Hix, L. M., Jackson, H., Nadolski, G. 2009-09-22. Structural carotenoid analogs for the inhibition and amelioration of disease. US 7,592,449. Assignee Cardax Pharmaceuticals, Inc. Originally published Oct. 12, 2006.
Lockwood, S. F., O’Malley, S., Jackson, H., Nadolski, G. 2010-04-06. Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation. US 7,691,901. Assignee Cardax Pharmaceuticals, Inc. Originally published Nov. 24, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L. M., Jackson, H., Nadolski, G. 2010-05-25. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease. US 7,723,327. Assignee Cardax Pharmaceuticals, Inc. Originally published Apr. 28, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L. M., Jackson, H., Nadolski. 2010-07-27. Carotenoid analogs or derivatives for controlling connexin 43 expression. US 7,763,649. Assignee Cardax Pharmaceuticals, Inc. Originally published Jan. 13, 2005.

Published U.S. and World Patent Applications top

Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease. US 2005/0004235. Assignee Hawaii Biotech Inc. Published Jan. 6, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease. US 2005/0009758. Assignee Hawaii Biotech Inc. Published Jan. 13, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid ester analogs or derivatives for controlling connexin 43 expression. US 2005/0009788. Assignee Hawaii Biotech Inc. Published Jan. 13, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid analogs or derivatives for controlling connexin 43 expression. US 2005/0009930. Assignee Hawaii Biotech Inc. Published Jan. 13, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease. US 2005/0026874. Assignee Hawaii Biotech Inc. Published Feb. 3, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid ester analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury. US 2005/0037995. Assignee Hawaii Biotech Inc. Published Feb. 17, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid ether analogs or derivatives for controlling C-reactive protein levels. US 2005/0049248. Assignee Hawaii Biotech Inc. Published Mar. 3, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid ester analogs or derivatives for controlling C-reactive protein levels. US 2005/0059635. Assignee Hawaii Biotech Inc. Published Mar. 17, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid analogs or derivatives for controlling C-reactive protein levels. US 2005/0059659. Assignee Hawaii Biotech Inc. Published Mar. 17, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease. US 2005/0065096. Assignee Hawaii Biotech Inc. Published Mar. 24, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid ether analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury. US 2005/0065097. Assignee Hawaii Biotech Inc. Published Mar. 24, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease. US 2005/0075316. Assignee Hawaii Biotech Inc. Published Apr. 7, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Pharmaceutical compositions including carotenoid analogs or derivatives for the inhibition and amelioration of disease. US 2005/0075337. Assignee Hawaii Biotech Inc. Published Apr. 7, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease. US 2005/0090469. Assignee Hawaii Biotech Inc. Published Apr. 28, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid analogs or derivatives for the inhibition and amelioration of disease. US 2005/0113372. Hawaii Biotech Inc. Published May 26, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury. US 2005/0143475. Assignee Hawaii Biotech Inc. Published Jun. 30, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L., Jackson, H. L., Nadolski, G. 2005. Carotenoid ether analogs or derivatives for controlling connexin 43 expression. US 2005/0148517. Assignee Hawaii Biotech Inc. Published Jul. 7, 2005.
Lockwood, S. F., O’Malley, S., Jackson, H. L., Nadolski, G. 2005. Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation. US 2005/0261254. Assignee Hawaii Biotech Inc. Published Nov. 24, 2005.
Lockwood, S. F., O’Malley, S., Jackson, H. L., Nadolski, G. 2006. Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation. US 2006/0058269. Assignee Hawaii Biotech Inc. Published Mar. 16, 2006.
Lockwood, S. F., Tang, P. C., Nadolski, G. T., Jackson, H. L., Fang, Z., Du, Y., Yang, M., Geiss, W. B., Williams, R., Burdick, D. C. 2006. Methods for the synthesis of zeazanthin. US 2006/0088905. Assignee Hawaii Biotech Inc. Published Apr. 27, 2006.
Lockwood, S. F., Tang, P. C., Nadolski, G. T., Jackson, H. L., Fang, Z., Du, Y., Yang, M., Geiss, W. B., Williams, R., Burdick, D. C. 2006. Methods for the synthesis of chiral dihydroxy ketone intermediates useful for the chiral synthesis of carotenoids. US 2006/0111580. Assignee Hawaii Biotech Inc. Published May 25, 2006.
Lockwood, S. F., Tang, P. C., Nadolski, G., Jackson, H. L., Fang, Z., Du, Y., Yang, M., Geiss, W., Williams, R., Burdick, D. 2006. Methods for the synthesis of lutein. US 2006/155150. Assignee Hawaii Biotech Inc. Published Jul. 13, 2006.
Lockwood, S. F., Tang, P. C., Nadolski, G., Jackson, H. L., Fang, Z., Du, Y., Yang, M., Geiss, W., Williams, R., Burdick, D. 2006. Methods for the synthesis of unsaturated ketone intermediates useful for the synthesis of carotenoids. US 2006/167319. Assignee Hawaii Biotech Inc. Published Jul. 27, 2006.
Lockwood, S. F., Tang, P. C., Nadolski, G., Jackson, H. L., Fang, Z., Du, Y., Yang, M., Geiss, W., Williams, R., Burdick, D. 2006. Methods for the synthesis of chiral dihydroxy intermediates useful for the chiral synthesis of carotenoids. US 2006/178538. Assignee Hawaii Biotech Inc. Published Aug. 10, 2006.
Lockwood, S. F., Tang, P. C., Nadolski, G., Jackson, H. L., Fang, Z., Du, Y., Yang, M., Geiss, W., Williams, R., Burdick, D. 2005. Methods for the synthesis of astaxanthin. US 2006/183185. Assignee Hawaii Biotech Inc. Published Aug. 17, 2006.
Lockwood, S. F., Tang, P. C., Nadolski, G., Jackson, H. L., Fang, Z., Du, Y., Yang, M., Geiss, W., Williams, R., Burdick, D. 2006. Methods for the synthesis of astaxanthin. US 2006/183947. Assignee Hawaii Biotech Inc. Published Aug. 17, 2006.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L. M., Jackson, H., Nadolski, G. 2006. Structural carotenoid analogs for the inhibition and amelioration of disease. US 2006/229446. Assignee Hawaii Biotech Inc. Published Oct. 12, 2006.
Lockwood, S. F., Nadolski, G. 2006. Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of visual disabilities. US 2006/270589. Assignee Hawaii Biotech, Inc. Published Nov. 30, 2006.
Lockwood, S. F., Nadolski, G. 2006. Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof. US 2006/270590. Assignee Hawaii Biotech, Inc. Published Nov. 30, 2006.
Lockwood, S. F., Nadolski, G., Frey, D. A., McLaws, M., King, T. J., Burdick, D. 2006. Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of proliferative disorders. US 2006/276372. Assignee Hawaii Biotech, Inc. Published Dec. 7, 2006.
Lockwood, S. F., Tang, P. C., Nadolski, G., Jackson, H. L., Fang, Z., Du, Y., Yang, M., Geiss, W., Williams, R., Burdick, D. 2006. Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates. US 2006/293545. Assignee Hawaii Biotech, Inc. Published Dec. 28, 2006.
Lockwood, S. F., Nadolski, G. 2006. Water-dispersible carotenoids, including analogs and derivatives. US 2007/15735. Assignee Hawaii Biotech, Inc. Published Jan. 18, 2007.
Lockwood, S. F. 2007. Structural carotenoid analogs or derivatives for the modulation of systemic and/or target organ redox status. US 2007/0238793. Assignee Hawaii Biotech, Inc. Published Oct. 11, 2007.
Lockwood, S. F., Tang, P. C., Nadolski, G., Jackson, H. L., Fang, Z., Du, Y., Yang, M., Geiss, W., Williams, R., Burdick, D., Braun, C. 2008. Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates. US 2008/0221377. Assignee Cardax Pharmacetuicals, Inc. Published Sep. 11, 2008.
Lockwood, S. F., Mason, R. P. 2008. Use of carotenoids and/or carotenoid derivatives/analogs for reduction/inhibition of certain negative effects of COX inhibitors. US 2008/0293679. Assignee Cardax Pharmaceuticals, Inc. Published Nov. 27, 2008.
Foss, B. J., Nadolski, G. T., Lockwood, S. F. 2009. Synthesis of carotenoid analogs or derivatives with improved antioxidant characteristics. US 2009/0099061. Assignee Cardax Pharmaceuticals, Inc. Published Apr. 16, 2009.
Lockwood, S. F., Mason, R. P. 2009. Carotenoid analogs and derivatives for the prevention of platelet aggregation. US 2009/0124574. Assignee Cardax Pharmaceuticals, Inc. Published May 14, 2009.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L. M., Jackson, H., Nadolski, G. Canadien Patent Application CPA 2,495,167. Analogues de carotenoides structuraux pour l’inhibition et la reduction de maladie. Assignee Hawaii Biotech, Inc. PCT publication date Feb. 5, 2004.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L. M., Jackson, H., Nadolski, G. European Patent Office EP 1,532,108. Structural carotenoid analogs for the inhibition and amelioration of disease. Assignee Hawaii Biotech, Inc. EP publication date May 25, 2005.
Lockwood, S. F., O’Malley, S., Watumull, D. G., Hix, L. M., Jackson, H., Nadolski, G. Patent Cooperation Treaty WO 2004/011423. Structural carotenoid analogs for the inhibition and amelioration of disease. Assignee Hawaii Biotech, Inc. WO publication date Feb. 5, 2004.
Lockwood, S. F., O’Malley, S., Jackson, H., Nadolski, G. Patent Cooperation Treaty WO 2005/102356. Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation. Assignee Hawaii Biotech, Inc. WO publication date Nov. 3, 2005.
Lockwood, S. F., Tang, P. C., Nadolski, G., Fang, Z., Du, Y., Geiss, W., Williams, R., Burdick, D. Patent Cooperation Treaty WO 2006/039685. Methods for synthesis of chiral intermediates of carotenoids, carotenoid analogs, and carotenoid derivatives. Assignee Hawaii Biotech, Inc. WO publication date Apr. 13, 2006.